Name: Yoshihiko Chiba
Home Address:
3-6-13-905 Ebara,
Shinagawa-ku, Tokyo 142-0063, Japan.
Tel: 81-3-3783-3440.
Mailing
Address:
Department of Pharmacology, School of Pharmacy,
Hoshi University,
2-4-41 Ebara,
Shinagawa-ku, Tokyo 142-8501,
Japan.
Tel: 81-3-5498-5787.
Sex:
Male
Marital
Status: Married
(wife's name: Fukiko Chiba), no child
Birthdate:
July 3, 1965
Birthplace: Sapporo,
Hokkaido, Japan
Nationality: Japanease
Education:
1990 Graduated
from Hoshi University, Tokyo.
1992 Completed
the M.S. Course of Pharmacology,
Hoshi University,
Tokyo.
1995 Completed
the Ph.D. Course of Hoshi University, Tokyo.
2001-2003 Postdoctoral fellow (NIH, USA)
Present position:
Associate of Professor
Department of Pharmacology, School of Pharmacy, Hoshi University, 2-4-41
Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Degree:
M.S., Hoshi University, 1992
Thesis, "A new model of allergic airway
hyperresponsiveness in rats and the mechanism of airway hyperresponsiveness."
Ph.D., Hoshi University, 1995
Thesis, "Mechanisms involved in the pathogenesis
of airway hyperresponsiveness in allergic asthma."
Qualification: Pharmacist.
Affiliated
organization:
1) Japanease Pharmacological Society
2) Pharmaceutical Society of Japan
3) Japanease Society of Allergology
4) Japanease Smooth Muscle Society
Research area: Respiratory
pharmacology
1) Bronchial asthma
2) Allergic rhinitis
Bibliography
1. Misawa, M., Kanai, Y. and Chiba, Y. Effects of the new antiallergic drug epinastine and ketotifen on repeated antigen challenge-induced airway hyperresponsiveness in rats. Arzneim.-Forsch. 41, 1277-1280, 1991.
2. Misawa, M. and Chiba, Y. Repeated antigenic challenge-induced airway hyperresponsiveness and airway inflammation in actively sensitized rats. Jpn. J. Pharmacol. 61, 41-50, 1993.
3. Chiba, Y. and Misawa, M. Strain differences in change in airway responsiveness after repeated antigenic challenge in three strains of rats. Gen. Pharmacol. 24, 1265-1272, 1993.
4. Misawa, M. and Chiba, Y. Inhibition of antigen-induced airway hyperresponsiveness in rats: effects of ozagrel (a thromboxane A2 synthase inhibitor) and of CV-3988 (a platelet activating factor antagonist). Res. Commun. Chem. Pathol. Pharmacol. 84, 341-349, 1994.
5. Chiba, Y. and Misawa, M. Antigen-induced airway hyperresponsiveness is associated with airway tissue NEP hypoactivity in rats. Life Sci. 55, 1919-1928, 1994.
6. Chiba, Y. and Misawa, M. Inhibition of neutral endopeptidase increases airway responsiveness to ACh in nonsensitized normal rats. J. Appl. Physiol. 78, 394-402, 1995.
7. Chiba, Y. and Misawa, M. Alteration in Ca2+ availability involved in antigen-induced airway hyperresponsiveness in rats. Eur. J. Pharmacol. 278, 79-82, 1995.
8. Chiba, Y. and Misawa, M. Characteristics of muscarinic cholinoceptors in airways of antigen-induced airway hyperresponsive rats. Comp. Biochem. Physiol. 111C, 351-357, 1995.
9. Chiba, Y., Yanagisawa, R. and Sagai, M. Strain and route differences in airway responsiveness to acetylcholone in mice. Res. Commun. Mol. Pathol. Pharmacol. 90, 169-172, 1995.
10. Misawa, M., Sato, J., Furukawa, Y., Chiba, Y. and Hosokawa, T. Abnormal modulation of cholinergic neurotransmission by opioid in hyperresponsive bronchus of rats. Gen. Pharmacol. 27, 441-444, 1996.
11. Chiba, Y. and Misawa, M. Characteristics of ?-adrenoceptors in airways of antigen-induced airway hyperresponsive rats. Pathophysiology 3, 157-161, 1996.
12. Tsuda, M., Chiba, Y., Suzuki, T. and Misawa, M. Upregulation of NMDA receptor subunit proteins in the cerebral cortex during diazepam withdrawal. Eur. J. Pharmacol. 341, R1-R2, 1998.
13. Chiba, Y., Sakai, H. and Misawa, M. Characterization of muscarinic receptors in rat bronchial smooth muscle in vitro. Res. Commun. Mol. Pathol. Pharmacol. 102, 205-208, 1998.
14. Chiba, Y. and Misawa, M. Molecular mechanisms of the hyperresponsiveness of airway smooth muscle in bronchial asthma. Folia Pharmacol. Jpn. 111, 249-256, 1998 (Abstr. in English)
15. Chiba, Y., Takada, Y., Miyamoto, S., Mitsui-Saito, M., Karaki, H. and Misawa, M. Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Br. J. Pharmacol. 127, 597-600, 1999.
16. Chiba, Y., Sakai, H., Suenaga, H., Kamata, K. and Misawa, M. Enhanced Ca2+ sensitization of the bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Res. Commun. Mol. Pathol. Pharmacol. 106, 77-85, 1999.
17. Chiba, Y. and Misawa, M. Probable involvement of the augmented agonist-induced Ca2+ sensitization of airway smooth muscle contraction in the pathogenesis of airway hyperresponsiveness. Folia Pharmacol. Jpn. 114, 185-190, 1999 (Abstr. in English)
18. Chiba, Y., Sakai, H., Arimoto, T., Takada, Y., Yoshikawa, T. and Misawa, M. Gq protein level increases concurrently with antigen-induced airway hyperresponsiveness in rats. Respir. Physiol. 121, 75-83, 2000.
19. Chiba, Y., Takada, Y., Sakai, H., Takeyama, H. and Misawa M. Acetylcholine-induced smooth muscle contraction of intrapulmonary small bronchi is augmented in antigen-induced airway hyperresponsive rats. Jpn. J. Pharmacol. 84, 221-224, 2000.
20. Chiba, Y., Arimoto, T., Yoshikawa, T. and Misawa, M. Elevated nitric oxide synthase activity concurrent with antigen-induced airway hyperresponsiveness in rats. Exp. Lung Res. 26, 535-549, 2000.
21. Chiba, Y. Probable involvement of the augmented agonist-induced Ca2+ sensitization of airway smooth muscle contraction in the pathogenesis of airway hyperresponsiveness. Proc. Hoshi Univ. 42, 7-11, 2000.
22. Chiba, Y., Sakai, H. and Misawa, M. Possible involvement of Gi3 protein in augmented contraction of bronchial smooth muscle from antigen-induced airway hyperresponsive rats. Biochem. Pharmacol. 61, 921-924, 2001.
23. Chiba, Y., Sakai, H. and Misawa, M. Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats. Br. J. Pharmacol. 133, 886-890, 2001.
24. Chiba, Y. and Misawa, M. Increased expression of G12 and G13 proteins in bronchial smooth muscle of airway hyperresponsive rats. Inflam. Res. 50, 333-336, 2001.
25. Chiba, Y., Takeyama, H., Sakai, H. and Misawa, M. Effects of Y-27632 on acetylcholine-induced contraction of intact and permeabilized intrapulmonary bronchial smooth muscles in rats. Eur. J. Pharmacol. 427, 77-82, 2001.
26. Sakai, H., Chiba, Y. and Misawa, M. Site difference in RhoA expression between rat bronchial and tracheal smooth muscle after antigen challenge — With reference to development of hyperresponsiveness. Inflam. Res. 50, 577-580, 2001.
27. Chiba, Y., Saitoh, N., Matsuo, K. and Misawa, M. Elevated nasal mucosal G protein levels and histamine receptor affinity in a guinea pig model of nasal hyperresponsiveness. Int. Arch. Allergy Immunol. 127, 285-293, 2002.
28. Chiba, Y., Sakai, H., Wachi, H., Sugitani, H., Seyama, Y. and Misawa, M. Upregulation of rhoA mRNA in bronchial smooth muscle of antigen-induced airway hyperresponsive rats. J. Smooth Muscle Res. 39, 221-228, 2003.
29. Sakai, H., Otogoto, S., Chiba, Y., Abe, K. and Misawa, M. TNF-alpha augments expression of RhoA in rat bronchus. J. Smooth Muscle Res. 40, 25-34, 2004.
30. Chiba, Y., Uchida, T., Sakai, H., Oku, T., Itoh, S., Tsuji, T. and Misawa, M. Acetylcholine-induced translocation of RhoA in freshly isolated single smooth muscle cells of rat bronchi. J. Pharmacol. Sci. 95, 479-482, 2004.
31. Chiba, Y., Ueno, A., Sakai, H. and Misawa, M. Hyperresponsiveness of bronchial but not tracheal smooth muscle in a murine model of allergic bronchial asthma. Inflam. Res. 53, 636-642, 2004.
32. Chiba, Y., Kusakabe, T. and Kimura, S. Decreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L1193-L1198, 2004.
33. Sakai, H., Otogoto, S., Chiba, Y., Abe, K. and Misawa, M. Involvement of p42/44 MAPK and RhoA protein in the augmentation of ACh-induced bronchial smooth muscle contraction by TNF-alpha in rats. J. Appl. Physiol. 97, 2154-2159, 2004.
34. Srisodsai, A., Kurotani, R., Chiba, Y., Sheikh, F., Young, H.A., Donnelley, R.P. and Kimura, S. Interleukin-10 induces expression of the Uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1. J. Biol. Chem. 279, 54358-54368, 2004.
35. Chiba, Y. and Misawa, M. The role of RhoA-mediated Ca2+ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness. J. Smooth Muscle Res. 40, 155-167, 2004.
36. Chiba, Y., Srisodsai, A., Supavilaic, P. and Kimura, S. Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation. Immunol. Lett. 97, 123-129, 2005.
37. Chiba, Y., Ueno, A., Shinozaki, K., Takeyama, H., Nakazawa, S., Sakai, H. and Misawa, M. Involvement of RhoA-mediated Ca2+ sensitization in antigen-induced bronchial smooth muscle hyperresponsiveness in mice. Respir. Res. 6, 4, 2005.
38. Sakai, H., Shirai, T., Yamamoto, M., Chiba, Y. and Misawa, M. Involvement of M3 muscarinic receptors in ACh-induced increase in membrane-associated RhoA of rat bronchial smooth muscle. Biol. Pharm. Bull. 28, 625-628, 2005.
39. Sakai, H., Hirano, T., Chiba, Y. and Misawa, M. Acetylcholine-induced phosphorylation of CPI-17 in rat bronchial smooth muscle: roles of Rho-kinase and protein kinase C. Can. J. Physiol. Pharmacol. 83, 375-381, 2005.
40. Sakai, H., Chiba, Y., Hirano, T. and Misawa, M. Possible involvement of CPI-17 in augmented bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Mol. Pharmacol. 68, 145-151, 2005.
41. Chiba, Y., Sakai, H., Yu, Y. and Misawa, M. Effects of repeated antigen exposure on endothelin-1-induced bronchial smooth muscle contraction and activation of RhoA in sensitized rats. J. Biochem. 137, 751-756, 2005.
42. Chiba, Y., Sakai, H. and Misawa, M. Endothelin-1-induced translocation of RhoA is mediated by ETA receptors in rat bronchial smooth muscle. Eur. J. Pharmacol. 517, 182-185, 2005.
43. Sakai, H., Hirano, T., Chiba, Y. and Misawa, M. Acetylcholine-induced phosphorylation and membrane translocation of CPI-17 in bronchial smooth muscle of rats. Am. J. Physiol. Lung Cell. Mol. Physiol. (in press)
44. Chiba, Y., Oshita, M., Matsuo, K., Sakai, H. and Misawa, M. Comparison of norepinephrine responsiveness of mucosal veins in vivo with that of isolated mucosal tissue in vitro in guinea pig nasal mucosa. Am. J. Rhinol. ?, ?-?, 2005.
45. Chiba, Y., Matsuo, K., Sakai, H., Abe, K. and Misawa, M. Increased expression of inducible nitric oxide synthase in nasal mucosae of guinea pigs with induced allergic rhinitis. Am. J. Rhinol. (in press)
46. Chiba, Y., Murata, M., Ushikubo, H., Yoshikawa, Y., Saitoh, A, Sakai, H., Kamei, J. and Misawa, M. Effect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in rats. Am. J. Respir. Cell Mol. Biol. (in press)
