Name : Renzhi Han PHD
Address
:
Howard Hughes Medical Institute
University of IOWA, College of Medicine
400 EMRB, IOWA City, IA 52242, USA
Tel
:
+1-319-335-6964
Fax : +1-319-335-6957
Employment Experience :
•
Research Associate (July 02, 2003-present), Howard Hughes Medical Institute,
University of Iowa College of Medicine.
•
NH&MRC Research Officer (February 03, 2003-June 20, 2003), Orthopedics,
School of Surgery, University of Western Australia.
•
Research Assistant (November-December, 2002), School of Anatomy and Human
Biology, University of Western Australia.
Education :
PhD :
School of Biomedical and Chemical Sciences, the University of Western Australia,
Perth, Australia. Commenced on March 1, 1999.
PhD with Distinction was conferred on May 26, 2003.
Graduation practice (B.Sc.):
Shanghai Institute of Physiology, Chinese Academy of Science, Shanghai, China.
February ~ May 1998.
B.Sc. in Physiology and Biophysics, Peking University,
Beijing, China. September 1994 ~ July 1998.
Invited Talks
•
2006 Muscle E-C Gordon Conference at Colby-Sawyer College in New London ,
New Hampshire, June 4-9, 2006.
•
“Defective membrane repair: a novel mechanism of muscular dystrophy”
at Department of Physiology, University of Western Australia, August 24, 2004.
Reviewer for Journal Articles
• Journal of Histochemistry and Cytochemistry
Awards, Fellowships and Grants
•
May 26 2003 Awarded “PhD with Distinction” by the University of
Western Australia
•
March 1999 – August 2002 Awarded International Postgraduate Research
Scholarship from the University of Western Australia.
•
March 1999 – August 2002 Awarded University Postgraduate Award, from
the University of Western Australia.
•
June 2002 Awarded departmental travel grant to attend the 5th Federation of
Asian and Oceanian Physiological Societies Congress 2002.
•
March 2001 Awarded travel grant from the University of Western Australia to
attend XXXIVth International Union of Physiological Sciences Congress 2001.
•
June 2001 Awarded travel award from Australian Academy of Sciences to attend
XXXIVth International Union of Physiological Sciences Congress 2001.
•
June 2001 Awarded travel award from Australian Physiological and Pharmacological
Society to attend XXXIVth International Union of Physiological Sciences Congress
2001.
•
1995-1996 Awarded Peking University Outstanding Student Scholarship.
•
October 1993 Awarded the Second Prize in Chinese Olympic Competition of Mathematics
for Senior High-School Students.
•
October 1993 Awarded the Third Prize in Chinese Olympic Competition of Chemistry
for Senior High-School Students.
Publications
Refereed Journal Articles
1.
Han, Renzhi and Bakker, A.J. (2003) The effect of chelerythrine on depolarization-induced
force responses in skinned fast skeletal muscle fibres of the rat. British
Journal of Pharmacology 138, 417-426.
2. Han, Renzhi, Suizu, K., Grounds, M. and Bakker,
A.J. (2003) Effect of Indomethacin on Force Responses and Sarcoplasmic Reticulum
Function in Skinned Skeletal Muscle Fibres and Cytosolic [Ca2+] in Myotubes.
American Journal of Physiology Cell Physiology 285, C881-C890.
3. Jiake Xu, Cathy Wang, Renzhi Han, Nathan Pavlos,
Tony Phan, James H. Steer, Anthony J. Bakker, David A. Joyce, Ming H. Zheng.
(2005) Evidence of reciprocal regulation between the high extracellular calcium
and RANKL signal transduction pathways in RAW cell derived osteoclasts. Journal
of Cellular Physiology. 202, 554-562.
4. Kirk H. M. Yip, Ming H. Zheng, James H. Steer,
Tindaro Matthew Giardina, Renzhi Han, Susan Z. Lo, Anthony J. Bakker, A. Ian
Cassady, David A. Joyce, Jiake Xu. (2005) Thapsigargin (TG) Modulates Osteoclastogenesis
via the Regulation of RANKL-Induced Signaling Pathways and Reactive Oxygen
Species Production. Journal of Bone and Mineral Research. 10.1359/JBMR.050324,
In Press.
5. Renzhi Han, and Anthony J. Bakker. (2005)
The Effect of the PKC inhibitor Calphostin C and the PKC agonist Phorbol 12-myristate
13-acetate on Regulation of Cytosolic Ca2+ in Mammalian Skeletal Muscle Cells.
Toxicology and Applied Pharmacology. In Press.
6. Renzhi Han, Miranda D. Grounds, Anthony J.
Bakker. (2005) Near-Membrane Cytosolic Ca2+ Levels and Ca2+ Transients Measured
in Myotubes and Isolated Myofibres from Normal and mdx Mice Using the Ca2+
Indicator FFP-18. Cell Calcium. In Revision.
7. Renzhi Han, Lyn Kirilak, Craig R. Willers,
Jiake Xu, Anthony J. Bakker, Nithiananthan Asokananthan, Geoffrey A. Stewart,
Peter Henry, David Wood, Ming H. Zheng. (2005) Human Chondrocytes Express
Protease-Activated Receptors: Possible Involvement of Thrombin-induced Cell
Proliferation and Migration. Journal of Cellular Biochemistry. In Revision.
Abstracts for Conferences
1.
Renzhi Han, Lyn Kirilak, Craig Willers, Ming-Hao Zheng. (2004) Human Chondrocytes
Express Protease-Activated Receptors: Possible Involvement of Thrombin-induced
Cell Proliferation and Migration. Australian and New Zealand Orthopaedic Research
Society,
2. Bakker AJ, Han R and Gounds M (2003) Near-membrane
cytosolic [Ca2+] levels and Ca2+ transients measured in myotubes grown from
normal and dystrophic (mdx) mice using the Ca2+ indicator FFP-18. Proceedings
of the Australian Physiological and Pharmacological Society, September 2003.
3. Bakker AJ, Han R, Gounds M and Takuya S (2002)
The effect of the phospholipase A2 inhibitors indomethacin and quinacrine
on depolarisation-induced force responses in skinned skeletal muscle fibres
of the rat. Proceedings of the Australian Physiological and Pharmacological
Society, September 2002.
4. Han, R., Gounds, M. and Bakker, A.J. (2002)
Chelerythrine reactivates depolarization-induced force responses after rundown
in skinned skeletal muscle fibres of the rat. Proceedings of the 5th Federation
of Asian and Oceanian Physiological Societies Congress, September 2002.
5. Han, R., Suizu, T., Gounds, M. and Bakker,
A.J. (2002) Phospholipase A2 inhibitors reactivates depolarization-induced
force responses after rundown in skinned skeletal muscle fibres of the rat.
Proceedings of the 13th Combined Biological Sciences, August 25th, 2002.
6. Han, R. and Bakker, A.J. (2001) The effect
of chelerythrine on low-frequency fatigue and post-fatigue force recovery
in skeletal muscle of the rat. Proceedings of the XXXIVth International Union
of Physiological Sciences Congress, August 2001.
7. Bakker, A.J. and Han, R. (1999) The effect
of phorbol 12-myristate 13-acetate and chelerythrine on depolarisation-induced
force responses in skinned skeletal muscle fibres. Proceedings of the Australian
Physiological and Pharmacological Society, September 1999.
8. Han, R. and Bakker, A.J. (1999) The effect
of chelerythrine on excitation-contraction coupling of skeletal muscle. Proceedings
of the 10th Combined Biological Sciences, August 27th, 1999.
Graduate Thesis
1.
Thesis for BSc: Modulation of GABAa and GABAc receptors on acutely isolated
carp retinal bipolar cells by zinc. Peking University Library, May 1998. (Distinction)
2. Thesis for PhD: Modulation of intracellular calcium handling by
inhibitors of protein kinase C and phospholipase A2 in skeletal muscle cells.
The University of Western Australia, November 2002. (Distinction)
Conference Presentations
•
New Directions in Biology and Disease of Skeletal Muscle, San Diego, CA, January
25 - 28, 2004.
•
The 5th Federation of Asian and Oceanian Physiological Societies Congress,
Kuala Lumpur, Malaysia, September 23-26, 2002.
•
The 13th Annual Meeting of Combined Biological Sciences, Perth, Australia,
August 2002.
•
The 34th International Union of Physiological Sciences Congress, Christchurch,
New Zealand, August 26-31, 2001.
•
Satellite Meeting of the 34th IUPS Congress, Melbourne, Australia, August
18-20, 2001.
•
The 11th Annual Meeting of Combined Biological Sciences, Perth, Australia,
August 2000.
•
The 10th Annual Meeting of Combined Biological Sciences, Perth, Australia,
August 1999.
Affiliation
•
Member of American Physiological Society, 2001-2005
•
Member of Australian Physiological and Pharmacological Society, 2001-2005
References
Dr
Anthony J Bakker (PhD supervisor)
Physiology Unit
School of Biomedical and Chemical Sciences
The University of Western Australia
Tel: +61-8-93807859
Professor Miranda Grounds (PhD co-supervisor)
School of Anatomy and Human Biology
The University of Western Australia
Tel: +61-8-93803486
Dr.
Jiake Xu
Molecular Orthopaedics Laboratory
School of Surgery and Pathology
The University of Western Australia
